In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus
Article Abstract:
A new approach for visualizing tumors whose fluorescence could be detected using telomerase-specific replication-competent adenovirus expressing green fluorescent protein (GFP) (OBP-401) is described. The results indicate that OBP-401 causes viral spread into the regional lymphatic area and selectively replicates in neoplastic lesions, resulting in GFP expression in metastatic lymph nodes.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Venture science: Climbing the ladder to telomerase, cognitive therapy and in situ hybridization
Article Abstract:
The 2006 Lasker Basic Award was given to three scientists for their prediction and discovery of telomerase, a remarkable RNA-containing enzyme that synthesizes the ends of chromosomes, protecting them and maintaining the integrity of the genome. The three honored scientists were Elizabeth H. Blackburn, Carol W. Greider and Jack W. Szostak.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Towering science: an ounce of creativity is worth a ton of impact
Article Abstract:
The Lasker Prize awarded in 2002, passed 22 years after the discovery of ubiquitination in 1968 is still waiting for recognition. Like the awards for phosphorylation and ubiquitination, the 2004 Lasker Awards in Basic and Clinical Medical research celebrated towering achievements that epitomize top-down scientific discoveries.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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