G-CSF induces E-selectin ligand expression on human myeloid cells
Article Abstract:
A study was conducted to investigate the molecular basis of clinical use of G-CSF which could result in vascular and inflammatory complications by analyzing the adherence of G-CSF-mobilized human peripheral blood leukocytes (ML) to inflamed (TNF-[alpha]-stimulated) vascular endothelium. The data indicate that the expression of E-selectin ligand on ML might reflect a direct G-CSF effect, as exposure to pharmacologically relevant G-CSF concentrations in vitro resulted in increase in expression of pertinent glycosyltransferases.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
Article Abstract:
A study was conducted using a model of soft-tissue ischema in athymic nude mice to investigate the potential impact of reduced oxygen tension on SDF-1 regulation. The result reveals that a marked increase in SDF-1 mRNA in ischemic tissue after surgery was directly proportional to the reduction in tissue oxygen tension, and resulted in a similar increase in SDF-1 protein expression.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The evidence base for tight blood pressure control in the management of type 2 diabetes mellitus. Effects of blood pressure drugs in patients with diabetes and kidney disease
- Abstracts: Case-finding instruments for depression in primary care settings
- Abstracts: Gene-environment interactions and the etiology of common complex disease. Trajectories of health for older adults over time: accounting fully for death
- Abstracts: IKK mediates ischemia-induced neuronal death. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells
- Abstracts: Clinical correlates of pain with amniocentesis. The effect of parenthood on perceived quality of life in teens