Gastric inhibitory polypeptide-dependent cortisol hypersecretion - a new cause of Cushing's syndrome

Article Abstract:

Cushing's syndrome may be caused by an increased cortisol response to gastric inhibitory polypeptide (GIP) in patients with nodular adrenal hyperplasia, or enlargement of the adrenal glands. Cushing's syndrome is a disorder characterized by excess secretion of the steroid hormone cortisol by the adrenal glands. Pituitary-adrenal gland function in a 48-year-old woman with Cushing's syndrome and nodular adrenal hyperplasia was compared to that of five other patients with Cushing's syndrome and four healthy individuals. The patient's blood levels of cortisol were low-to-normal between meals and higher than normal after meals. Her blood levels of cortisol increased after ingestion of oral glucose (sugar) or after lipid-rich or protein-rich meals, but not after receiving intravenous (IV) glucose. Blood levels of cortisol increased after IV administration of GIP for one hour in the patient, but not in the four healthy individuals.

Causes of, Adrenocortical hormones

---

Propranolol therapy for ectopic beta-adrenergic receptors in adrenal Cushing's syndrome

Article Abstract:

An unusual case of Cushing's syndrome possibly caused by an abnormal proliferation of beta-adrenergic receptors in the adrenal glands is examined. In a 56-year-old man situations such as induced low blood sugar and stress that caused an increase in certain hormones, catecholamines, resulted in a corresponding increase in his cortisol levels. The adrenal tissue was found to have a high number of beta-adrenergic receptors, known to mediate the actions of catecholamines. The diagnosis was supported by the correction of the patient's cortisol levels with treatment with propranolol, a drug that blocks these receptors.

Drug therapy, Propranolol hydrochloride, Propranolol, Catecholamines, Beta adrenoceptors, Adrenergic beta receptors

---

Leuprolide acetate therapy in luteinizing hormone-dependent Cushing's syndrome

Article Abstract:

The case is reported of a 63-year-old woman who had Cushing's syndrome caused by luteinizing hormone. This is a natural hormone in the body involved in the production of eggs in the ovary. Cushing's syndrome is caused by an excess of cortisol, another hormone produced by the adrenal glands. In her case, luteinizing hormone stimulated the production of cortisol. Her condition only occurred during pregnancy and became constant after menopause. She was given the drug leuprolide acetate, which suppressed the production of luteinizing hormone and eliminated the symptoms of Cushing's sydrome.

Case studies, Leuprolide, Luteinizing hormone

Similar abstracts:

• Abstracts: Sexual health and the respiratory patient. Recognition, prevention and management of sputum retention. A guide to assessing sputum
• Abstracts: Angioarchitecture of monochorionic placentas in relation to the twin-twin transfusion syndrome. Placental transport rather than maternal concentration of amino acids regulates fetal growth in monochorionic twins: implications for fetal origin hypothesis
• Abstracts: Evolving strategies for the management of atrial fibrillation: the role of amiodarone. Low-dose amiodarone for maintenance of sinus rhythm after cardioversion of atrial fibrillation or flutter
• Abstracts: Fracture incoidence in relation to the pattern of use of hormone theraphy in postmenopausal women. Thyroid nodules in the population living around Chernobyl
• Abstracts: Isolated systolic hypertension and subclinical hypertension and subclinical cardiovascular disease in the elderly: initial findings from the cardiovascular health study

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.