Genetic identification of pregnancies responsible for choriocarcinomas after multiple pregnancies by restriction fragment length polymorphism analysis

Article Abstract:

Choriocarcinoma is a type of cancer that grows from trophoblasts (outer layer of cells in a developing embryo), from hydatid moles (uterine mass arising from a degenerating or poorly developed egg), and from normal or other types of pregnancies. It is important to determine the source of choriocarcinomas to understand how such tumors originate and develop. Genetic studies can determine which pregnancy is responsible for the tumor by showing identical DNA compositions. A relatively new laboratory technique to analyze DNA uses restriction enzymes, a type of enzyme that cuts DNA only at certain small sequences. The similarities in lengths of polymorphisms, the different DNA chains that remain (depending on whether they contain the sequences recognized by restriction enzymes), identify related entities. The cases of two patients with choriocarcinomas in which the tumor was genetically analyzed by restriction fragment length polymorphism analysis are described. The first patient had a choriocarcinoma removed six weeks after her third pregnancy, and it was determined that the tumor originated from this last pregnancy. The second patient had two normal deliveries and then developed a hydatid mole; analysis showed that the tumor developed from the mole. This report illustrates that restriction fragment length polymorphism analysis can be effective in identifying the source of choriocarcinoma. (Consumer Summary produced by Reliance Medical Information, Inc.)

Usage, Causes of, Complications and side effects, Genetic aspects, Pregnancy, Complications of, Pregnancy complications, Restriction enzymes, DNA, DNA restriction enzymes, Molar pregnancy, Hydatidiform mole, Choriocarcinoma

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The incidence of positive Kleihauer-Betke test in low-risk pregnancies and maternal trauma patients

Article Abstract:

A study is conducted to determine the incidence of positive Kleihauer-Betke (KB) test in low-risk, third trimester patients and compare them with historical control patients who received KB tests for maternal trauma evaluations. The results suggest that the incidence of a positive KB test in low-risk pregnancies does not differ from maternal trauma patients.

Care and treatment, Wounds and injuries, Injuries, Patients, Pregnancy

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Gestational diabetes mellitus: metabolic and blood glucose parameters in singleton versus twin pregnancies

Article Abstract:

Twin pregnancies are more likely to be complicated by gestational diabetes than singleton pregnancies. Gestational diabetes is a form of diabetes that first occurs in pregnancy.

Health aspects, Diabetes in pregnancy, Gestational diabetes, Pregnancy, Multiple, Multiple pregnancy

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