Virologic characterization of HIV type 1 with a codon 70 deletion in reverse transcriptase
Article Abstract:
The study of the drug susceptibility, relative infectivity, and fitness of viruses carrying [DELTA]70 and associated HIV-1 reverse transcriptase (RT) mutations show that [DELTA]70 enhances resistance to certain purine and pyrimidine analogues and contributes to multinucleoside resistance in the appropriate viral genetic background.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2007
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Prevalence of detection and dynamics of selection and reversion of K65R mutation in nucleoside reverse transcriptase inhibitor-experienced patients failing an antiretroviral regimen
Article Abstract:
The emergence of Nucleotide Reverse Transcriptase Inhibitor (NRTI) resistant HIV mutants can be a major cause of antiretroviral treatment failure. It is found that the use of a programmed treatment interruption strategy could be sufficient to obtain a reversion of the K65R mutation.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2005
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