HIV heterosexual transmission in hemophilia couples: lack of relation to T4 number, clinical diagnosis, or duration of HIV exposure

Article Abstract:

The spread of human immunodeficiency virus (HIV) by heterosexual relations from hemophiliacs infected with HIV to their female partners is low. The length of time of exposure to HIV before infectivity and the immunologic parameters of the infected individual were examined in 45 HIV-infected hemophiliacs who were being treated at the Hemophilia Center of Western Pennsylvania, along with their female partners. Six out of 45 (13 percent) of the female partners of HIV infected hemophiliacs developed antibodies against HIV, which is indicative of infection. The average time from the first exposure to the development of antibodies against HIV was 10.4 months. This differed from the average time from the first exposure to the most recent exposure for women who did not develop antibodies against HIV, which was 54 months. Transmission of the virus did not appear to be related to the presence of the virus in lymphocytes in the blood, or to the levels of p24, one of the proteins of HIV that is used as diagnostic test and measures the level of virus in the body. Hemophiliacs that transmitted the virus to their sexual partners had no symptoms of HIV infection. Thus, transmission of HIV occurred in an early stage of infection. When immunologic status of the hemophiliac was examined at the time that infection was detected in his partner, his status was similar to those who did not pass the virus to their partners. Sexual practices were analyzed, and there were no differences between the type, frequency of activity, or use of condoms between couples where the virus was transmitted and those were no transmission occurred. No correlations could be found between the clinical or immunological status and sexual practices between the hemophiliacs and their female sexual partners and the transmission of HIV. (Consumer Summary produced by Reliance Medical Information, Inc.)

---

Cumulative risk for AIDS and other HIV outcomes in a cohort of hemophiliacs in Western Pennsylvania

Article Abstract:

AIDS has now become the leading cause of death among hemophiliacs. Although hemophiliacs account for less than one percent of the total number of AIDS cases in the US, over 5 percent of hemophiliacs have AIDS, and over half have become infected with the AIDS virus. These patients provide a unique population for observing the progression of AIDS. They have few other risk factors, and are unlikely to be re-exposed to AIDS. They also have typically been under close medical supervision. The progression of the disease has been monitored in a cohort of 84 hemophiliacs infected with the AIDS virus; the dates of seroconversion to HIV-positive (human immunodeficiency virus) were known for all patients. The results showed that the length of the period of infection and the age of the patient have significant influence on the likelihood of developing AIDS. Using the Kaplan-Meier method of estimation, 12, 28, and 49 percent of infected patients are likely to develop AIDS by 4, 6, and 7.5 years after infection, respectively. Over the age of 30, an infected individual has a 49 percent chance of developing AIDS within six years of infection. Between 18 and 30, the chance of developing AIDS within six years of infection falls to 24 percent, and under the age of 18 the chance falls to 5 percent. Age also significantly affects the survival of the patient once the symptoms of AIDS develop. Patients over 40 have a 24 percent chance of surviving for a year after diagnosis, while patients under 40 have a 52 percent chance of surviving for the same period. (Consumer Summary produced by Reliance Medical Information, Inc.)

Patient outcomes, Mortality, Demographic aspects

---

Heterosexual HIV-1 transmission and viral load in hemophilic patients

Article Abstract:

HIV-infected men with hemophilia may be more likely to transmit the virus to their female sex partners if they have a high concentration of the virus in their blood. Many female partners of HIV-infected hemophiliacs do not contract HIV despite participating in unprotected sex. Researchers measured the viral load of 39 men with hemophilia and HIV infection. Sixty percent of men whose partners became infected with HIV had high viral loads, compared to only 9% of men who did not transmit the virus. High viral load may increase the risk of infection from heterosexual sex.

Sexual behavior, Measurement, Women, HIV infections, HIV patients, HIV infection in women, Viremia, Viral load

Similar abstracts:

• Abstracts: Bilateral transvaginal sacrospinous colpopexy: preliminary experience. Vaginal subtotal hysterectomy and sacrospinous colpopexy: an option in the management of uterine prolapse
• Abstracts: Impact of Medicare coverage on basic clinical services for previously uninsured adults. Unmet Health Needs of Uninsured Adults in the United States
• Abstracts: A nosocomial outbreak of Salmonella enteritidis infection due to the consumption of raw eggs. Risk factors for infection with plasmid-mediated high-level tetracycline resistant Neisseria gonorrhoeae
• Abstracts: Pyridoxine supplementation of lactating mothers: relation to maternal nutrition status and vitamin B-6 concentrations in milk
• Abstracts: Low avidity antibodies to double stranded DNA in systemic lupus erythematosus: a longtitudinal study of their clinical significance

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.