HLA antigen familial study in complete Behcet's syndrome affecting three sisters

Article Abstract:

A study of HLA typing in a family in which three sisters have complete Behcet's syndrome is presented. Behcet's syndrome is a chronic inflammatory disorder of small blood vessels characterized by oral and genital ulcers, skin lesions and eye disease. It primarily affects people of Asian and Mediterranean origin. The cause of Behcet's syndrome is unknown, but it has been associated with a particular HLA antigen - HLA-B51. In this Spanish family, all six siblings are HLA-B51, but only the sisters have the disease. The mother has recurrent mouth ulcers but no other symptoms of Behcet's syndrome. Following HLA typing, the sisters were all found to have an identical HLA phenotype. The father and one brother also had this HLA phenotype, but neither of them had Behcet's syndrome. This suggests that either hormones or the HLA inherited from the mother may play a role in the sister's development of Behcet's syndrome.

Case studies, Genetic aspects, HLA histocompatibility antigens, HLA antigens, Behcet's disease, Behcet's syndrome

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Serum soluble interleukin-2 receptor levels in familial Mediterranean fever

Article Abstract:

Increases in interleukin-2 receptor (IL-2R) levels may be associated with increased disease activity in patients with familial Mediterranean fever (FMF). IL-2 is a protein that helps stimulate the immune response. Blood levels of IL-2R were measured in 17 patients with stable FMF, 24 patients with active FMF, 20 patients with active rheumatoid arthritis, and 24 healthy volunteers (control group). IL-2R levels were similar for patients with active FMF and rheumatoid arthritis but higher than the control group or those with stable FMF. IL-2 levels were higher during the active phase among patients tested during both phases.

Measurement, Development and progression, Interleukin-2, Familial Mediterranean fever, Periodic disease

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Bisphosphonate therapy of reflex sympathetic dystrophy syndrome

Article Abstract:

It appears that biphosphonate treatment is effective in patients with reflex sympathetic dystrophy syndrome (RSDS). RSDS causes pain in the limbs. Measurements of limb function and bone mineral content (BMC) were made before and after 20 patients with RSDS were treated with either biphosphonate or placebo injections. Limb motion and BMC improved significantly among patients treated with biphosphonate. No improvement was seen in patients treated with placebo. Patients previously treated with placebo showed similar improvement when later treated with biphosphonate.

Evaluation, Drug therapy, Bone diseases, Diphosphonates

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