HLA class I associations of ankylosing spondylitis in the white population in the United Kingdom
Article Abstract:
It appears that many patients with ankylosing spondylitis (AS) carry the human leukocyte antigen-B27 (HLA-B27) and HLA-B60 gene sequences. However, HLA-B27 subtypes do not seem to be useful markers for AS susceptibility. The HLA gene complex codes for immune proteins. Researchers compared the frequency of HLA-B27 and HLA-B60 sequences among 284 white patients with AS (study group) and 5926 white bone marrow donors (controls). Ninety-four percent of the study group carried HLA-B27 while only 9.5% of the controls carried this sequence. Among study group patients and controls carrying HLA-B27, 11.9% and 3.6% also tested positive for HLA-B60, respectively. Among these participants carrying the HLA-B27 sequence, three of 172 study group patients and five of 154 controls carried the HLA-B*2702 subtype sequence. There were similar comparisons for the other subtypes. Among study group patients and controls not carrying HLA-B27, more study group patients tested positive for HLA-B60 (19%) than controls (6.2%).
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1996
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Evidence of impaired cartilage/bone turnover in patients with active ankylosing spondylitis
Article Abstract:
Measuring pyridinoline (PYR) in the urine may be preferable to measuring other bone proteins and enzymes for monitoring bone deterioration in patients with ankylosing spondylitis (AS). AS is a long-term inflammatory disease that can cause joints to ankylose, or fuse. PYR is a molecule that forms cross-links in bone and is excreted in the urine as bone deteriorates. Researchers analyzed both blood and urine samples of 62 patients with AS and 50 healthy volunteers (the control group). PYR urine levels were significantly higher in patients with AS compared to the control group. There were no significant differences in the blood levels of other bone proteins and enzymes in the AS patients compared to the healthy controls. This indicates that bone turnover in AS patients is impaired.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1995
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Ankylosing spondylitis, IgA, and transforming growth factors
Article Abstract:
It is possible that transforming growth factor beta (TGFB) plays an important role in the development of ankylosing spondylitis (AS) and psoriasis. AS is a long-term inflammatory disease which first affects the spine and progresses to other joints and organ systems of the body. As AS progresses, the joints may ankylose, or fuse. TGFBs are a family of molecules involved in the development and repair of cartilage and bone. A similar immune response seems to cause both psoriasis and AS. A researcher has proposed two hypotheses that may explain this immune response. One suggests that lymph cells stimulate the production of TGFB, causing AS. The other suggests that lymph cells may produce a protein called interferon gamma causing the inflammatory diseases of both AS and psoriasis.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1995
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