High levels of coagulation factor XI as a risk factor for venous thrombosis

Article Abstract:

Many patients with a history of deep vein thrombosis may have elevated blood levels of factor XI. Factor XI is involved in blood clotting, which is abnormal in patients with deep vein thrombosis. These patients have excessive clotting, and are predisposed to develop blood clots in their legs. In a study of 474 patients with deep vein clotting and 474 healthy volunteers, those who had the highest factor XI levels had twice the risk of deep vein thrombosis as those with the lowest levels.

Health aspects, Blood coagulation factors

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Oral contraceptives and the risk of venous thrombosis

Article Abstract:

The introduction of so-called third generation oral contraceptives that contain less estrogen than first-generation OCs has not significantly lowered the risk of abnormal blood clotting. Women with existing risk factors for cardiovascular disease or a history of abnormal blood clotting should probably avoid using oral contraceptives.

Complications and side effects, Oral contraceptives, Thrombosis

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Hyperhomocysteinemia as a risk factor for deep-vein thrombosis

Article Abstract:

High levels of homocysteine in blood plasma may increase the risk of deep-vein thrombosis, clots that obstruct veins. Researchers analyzed homocysteine levels in the plasma of 269 people with deep-vein thromboses and 269 healthy people (controls) matched by age and sex. A total of 28 (10%) of the people with thromboses and 13 (5%) of the healthy people had homocysteine levels above 18.5 micromoles per liter, which was the 95th percentile in the control group. The risk of thrombosis appeared to be 2.5 times greater in people with homocysteine levels above this mark than in people with levels below this mark. The correlation between high homocysteine levels and thrombosis was stronger among women than among men. The risk associated with high homocysteine levels appeared to be independent of other risk factors, such as low levels of the clotting-factor inhibitors protein C, protein S, and antithrombin.

Blood, Blood chemical analysis

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