Histamine-2 receptor antagonists do not alter serum ethanol levels in fed, nonalcoholic men

Article Abstract:

Histamine-2 (H-2) receptor antagonists may not affect blood levels of ethanol, or alcohol, in nonalcoholic men after moderate consumption of alcohol on a full stomach. Patients suffering from peptic-acid diseases are often treated with H-2 receptor antagonists. Twenty-three healthy nonalcoholic men between 21 and 35 years old were treated for seven days each with 400 milligrams (mg) of cimetidine twice a day, 20 mg of famotidine twice a day, 150 mg of nizatidine twice a day and 150 mg of rantidine twice a day and no treatment. Maximum blood levels of ethanol did not differ significantly during any of the treatments. Average blood levels of ethanol also did not differ significantly during any of the treatments. Some H-2 receptor antagonists are planned over-the-counter sale. Their affect on blood levels of ethanol is an important factor in evaluating the safety of these drugs.

Alcohol, Ethanol

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Do histamine-2 receptor antagonists influence the metabolism of ethanol?

Article Abstract:

The effect of histamine-2 (H-2) receptor antagonists on the metabolism of ethanol, or alcohol, is controversial. H-2 receptor antagonists are a group of drugs mainly used to treat patients suffering from acid-peptic diseases. A research study found that commercially available H-2 receptor antagonists did not affect the metabolism of alcohol. One concern is that H-2 receptor antagonists can unexpectedly increase blood levels of alcohol after ingestion of large amounts of alcohol. Part of this controversy is fueled by the debate over the metabolism of alcohol. After imbibing alcohol, a certain portion may be metabolized by the mucosal lining of the stomach. All of the alcohol that reaches the peripheral circulation is metabolized by the liver. H-2 receptor antagonists may affect the metabolism of alcohol because they inhibit gastric metabolism.

Editorial, Alcohol metabolism

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The relation of passage of gas and abdominal bloating to colonic gas production

Article Abstract:

Peoples' perceptions of intestinal gas, as indicated by feelings of bloatedness, may not necessarily correspond with actual gas production. Researchers evaluated the flatulence frequency, gas production, and gaseous reports of 25 healthy volunteers when given placebo for one week followed by a week of one of three fiber laxative preparations: lactulose, psyllium, or methylcellulose. Participants reported an increase in flatulence frequency from 10 times per day to 19 times per day with lactulose but no significant increase with the other two preparations. Participants also reported increased feelings of bloatedness with all preparations. However, there was not a corresponding increase but rather a decrease in measured gas production in these participants.

Causes of, Flatulence, Gastrointestinal gas

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