Hormone replacement therapy in breast cancer survivors: a cohort study

Article Abstract:

Women who have survived breast cancer may not have an increased risk of recurrence with subsequent hormone replacement therapy. Researchers compared 41 breast cancer survivors receiving hormone replacement therapy (HRT) after completing breast cancer treatment to 82 breast cancer survivors not receiving HRT. HRT users had similar rates of survival and recurrence as did nonusers. Both groups had similar rates of cancer before a diagnosis of breast cancer. Six HRT users had recurrences of breast cancer; two died. Seven women who did not use HRT had recurrent cancer and died. HRT may prevent osteoporosis and symptoms of menopause in postmenopausal women, and may be helpful for breast cancer survivors. A combination of tamoxifen and HRT may not diminish the benefits of either.

Care and treatment, Evaluation, Breast cancer, Hormone therapy

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Case report of interferon alfa therapy for multiple myeloma during pregnancy

Article Abstract:

Healthy infants can be born even though the mother has been treated for cancer with interferon alpha. A woman undergoing interferon alpha treatment for multiple myeloma was discovered to be pregnant. Therapy was discontinued. She gave birth to a term, healthy fetus. This prompted a search of the literature. Ten additional cases were found of women treated during pregnancy with interferon alpha. No adverse effects were found in the fetus, although theoretically interferon alpha could cause miscarriage or congenital anomalies. More information is needed about the safety of this drug in pregnancy. For example, it is not known whether interferon alpha can cross the placenta.

Research, Physiological aspects, Drug therapy, Diseases, Pregnant women, Interferon alpha, Multiple myeloma, Teratogenesis

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The effect of route of delivery on regression of abnormal cervical cytologic findings in the postpartum period

Article Abstract:

Some types of cervical dysplasia in pregnant women may regress if the woman delivers the baby vaginally. Cervical dysplasia is an abnormality of the cervix that can be a precursor of cancer, and it often regresses after pregnancy. Researchers analyzed the regression of cervical dysplasia in 138 pregnant women with an abnormal Pap smear. Twenty-one percent had a cesarean and 70% delivered vaginally. Sixty percent of the women with severe cervical dysplasia who delivered vaginally experienced regression, compared to none of the women who had a cesarean.

Health aspects, Development and progression, Childbirth, Delivery (Childbirth), Cervix dysplasia

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