Long-term survivors with HIV-1 infection: incubation period and longitudinal patterns of CD4+ lymphocytes

Article Abstract:

Ten to twenty percent of those infected with the AIDS virus (HIV) may remain disease-free for up to 20 years. Researchers studied long-term survivors in the Multicenter AIDS Cohort Study (MACS), which began in 1984. Of the 4,954 homosexual and bisexual men enrolled at that time, 1,809 were HIV-positive. Of these, 56 had been followed at least 5.5 years, had never taken zidovudine (AZT) and had regular blood lymphocyte measurements documenting their healthy status. They were compared to 56 men whose CD4 lymphocytes had dropped moderately (moderate decliners) and 56 whose CD4 lymphocytes had dropped substantially (fast decliners). Statistical calculations indicated that 32% to 40% of infected people would remain disease-free 12 years after becoming HIV-positive and 10% to 17% would remain disease-free up to 20 years. By the end of 1993, 87% of the fast decliners had developed AIDS, compared to 29% of the moderate decliners and 4% of the healthy men. Eighty-four percent of the fast decliners had died, compared to 20% of the moderate decliners and none of the healthy men.

Measurement, Development and progression, CD4 lymphocytes

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Lack of associations between HLA class II alleles and resistance to HIV-1 infection among white, non-Hispanic homosexual men

Article Abstract:

An attempt is made to identify associations of HLA class II alleles with resistance or susceptibility to HIV-1 infection among white, non-Hispanic homosexual men in the Multicenter AIDS Cohort Study (MACS). Results were detailed and other genetic factors in the HLA class II-TAP region of the major histocompatibility complex might be involved.

Science & research, Research, Influence, AIDS (Disease), AIDS research, HLA class II antigens

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