Human papillomavirus testing as triage for atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesions: sensitivity, specificity, and cost-effectiveness
Article Abstract:
The human papillomavirus (HPV) test approved by the Food and Drug Administration (FDA) does not appear to be a cost-effective way to further classify patients with questionable Papanicolaou smear tests. The effectiveness of using the FDA-approved HPV test was compared with repeat Papanicolaou testing among 462 women with initially questionable Papanicolaou smear tests. These women also underwent confirmatory tissue sampling tests. Both strategies were equally effective in differentiating women with cervical cancer. However, the HPV test cost twice as much as repeat Papanicolaou testing.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1997
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Is human papillomavirus testing of value in clinical practice?
Article Abstract:
It is probably not necessary to screen women with a certain abnormal Pap smear for human papillomavirus. This virus has been linked to cervical cancer. Researchers reviewed studies of women whose Pap smear showed atypical squamous cells of undetermined significance (ASCUS) who were tested for papillomavirus. Most of the studies had varying results. Cytologic screening and physical examination of the cervix using a technique called colposcopy appeared to be as effective as papillomavirus testing in detecting cervical cancer.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1999
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The effect of time interval between referral and colposcopy on detection of human papillomavirus DNA and on outcome of biopsy
Article Abstract:
Some human papillomavirus infections of the uterine cervix may go away spontaneously, especially if the virus is one of the types that does not necessarily cause cervical cancer. Researchers studied 1,006 women who were referred for a biopsy because they had an abnormal Pap smear. In many of the women, the biopsy done between two to four months later showed a normal cervix. This means the infection cleared spontaneously.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2003
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