Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1
Article Abstract:
Transplantation of autologous human hematopoietic fetal liver [CD34.sup.+] cells into nonobese diabetic severe combined immune deficiency (NOD/SCID) mice previously implanted with human fetal thymic and liver tissues results in long-term, systemic human T-cell homeostasis. T cells in these mice generate human major histocompatibility complex class I- and class II-restricted adaptive human immune responses to Epstein-Barr virus infection and are activated by human dendritic cells to mount a potent T-cell immune response to superantigens.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis
Article Abstract:
The development of recombinant cell-penetrating forms of suppressor of cytokine signaling (SOCS) 3 (CP-SOCS3) for intracellular delivery to counteract staphylococcal enterotoxin B (SEB), lipopolysaccharide (LPS) and lectin concanavalin A (ConA) -induced inflammation is discussed. CP-SOCS3 reduces production of inflammatory cytokines and attenuates liver apoptosis and hemorrhagic necrosis.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Immune privilege or inflammation: insights into the fas ligand enigma
Article Abstract:
The biological functions of Fas ligand (FasL) are examined, focusing on research that indicates it elicits both an immunological and inflammatory effect. Topics include FasL's role in transplantation and in combatting tumors; FasL expression in several cancers; a description of FasL's anti-inflammatory effects; and a history of the research involving FasL.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Reporting randomized controlled trials: an experiment and a call for responses from readers. CONSORT Revised--Improving the Reporting of Randomized Trials
- Abstracts: Impact of a risk-based prevention policy on neonatal group B streptococcal disease. Introduction of the new Centers for Disease Control and Prevention group B streptococcal prevention guideline at a large West Coast health maintenance organization
- Abstracts: Are histopathologic chorioamnionitis and funisitis associated with metabolic acidosis in the preterm fetus? Effect of gestational age and hypoxia on activity of ribonucleic acid polymerase in fetal guinea pig brain
- Abstracts: The effect of different diagnostic criteria on the prevalence of dementia. A reevaluation of the duration of survival after the onset of dementia