Identification of a clonal form of HIV in early Kaposi's sarcoma: evidence for a novel model of oncogenesis, "sequential neoplasia."
Article Abstract:
HIV may play an early role in the development of Kaposi's sarcoma (KS). Tissue samples were taken from four patients with KS who died from complications of HIV disease. Samples were taken from KS lesions and from areas where no KS was apparent. The samples were evaluated using inverse polymerase chain reaction (ICPR) to detect HIV DNA. Clonal ICPR products were identified in a sample taken from an early KS lesion of the bowel. Additionally, HIV-expressing macrophages were identified in an area next to the tumor. These macrophages were also producing KS growth factors. No clonal ICPR products were identified in a sample from the same patient taken from an unaffected part of the bowel. No ICPR products were identified in samples from more advanced lesions of the gastrointestinal tract or lymph nodes.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1995
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The natural history and molecular heterogeneity of HIV-associated primary malignant lymphomatous effusions
Article Abstract:
Primary malignant lymphomatous effusions seem to occur late in the progression to AIDS and may have a poor prognosis. This type of lymphoma occurs as fluid in body cavities, including the abdomen, lungs and the sac around the heart. Researchers followed 8 HIV-infected patients who had this lymphoma. All had CD4 T cell counts less than 200, indicating severe AIDS. In 5 patients, the main symptom was an enlarged abdomen from fluid in the peritoneal cavity. Most of the patients were too sick to benefit from chemotherapy. The average survival was 60 days. At autopsy, all were found to be infected with human herpesvirus 8.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
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Effect of antiviral drugs used to treat cytomegalovirus end-organ disease on subsequent course of previously diagnosed Kaposi's sarcoma in patients with AIDS
Article Abstract:
Foscarnet may be effective in preventing the progression of Kaposi's sarcoma (KS). KS is a skin tumor that occurs often in HIV patients. Researchers analyzed the progression of KS in 66 patients who were taking foscarnet or ganciclovir to treat cytomegalovirus infection. All of the patients also had a history of KS. In the patients taking foscarnet, it took an average of 211 days for a new tumor to develop or for an existing one to get bigger. In the patients taking ganciclovir, it took an average of 22 days.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1999
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