Identification of spirochetes related to Treponema pallidum in necrotizing ulcerative gingivitis and chronic periodontitis

Article Abstract:

Spirochetes are an order of bacteria that includes many varied species. Many species of spirochetes have been found in the gum tissues of patients with necrotizing ulcerative gingivitis and chronic periodontitis, both serious mouth inflammations. However, finding these bacteria in association with these diseases does not necessarily mean they caused the conditions; the bacteria may well have seized the opportunity to infect tissues that were already diseased. Determining the cause of these diseases is complicated by the fact that some spirochetes cannot be grown in the laboratory. While many bacteria grow freely under laboratory conditions, spirochetes such as Treponema pallidum and Treponema pertenue cannot as yet be cultivated in the laboratory. These are the causative organisms, respectively, of syphilis and the tropical disease yaws. Since these and other spirochetes cannot be investigated by studies relying upon cultivation techniques, a study using immunological methods was conducted. Using antibodies that react with very specific antigen molecules found on specific species of spirochetes, it was possible to demonstrate the presence of bacteria in the mouth lesions that had not been previously characterized. In 11 of 17 patients with necrotizing ulcerative gingivitis and in 10 of 19 patients with periodontitis, it was possible to identify spirochetes that possessed molecules very similar to some specific antigens of the syphilis organism T. pallidum. Similar spirochetes were not found in any of the 24 healthy subjects tested. The immunologically reactive molecules that the bacteria from the patients shared with T. pallidum are thought to be restricted to bacteria that cause disease. The observation of the close relationship between the bacteria from the patients with the disease-causing organism T. pallidum suggest that these bacteria may be intimately involved in the development and progression of necrotizing ulcerative gingivitis and periodontal disease. (Consumer Summary produced by Reliance Medical Information, Inc.)

Causes of, Periodontal disease, Periodontal diseases, Spirochetes

---

A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection

Article Abstract:

Penicillin G benzathine therapy appears to be adequate for treating syphilis even in HIV-infected patients. Of 541 patients enrolled in a trial of penicillin G benzathine alone or penicillin G benzathine plus amoxicillin and probenecid, 101 were HIV-positive. Neither treatment was more effective than the other and the only treatment failure in either group occurred in an HIV-positive patient. In about 17%-18% of the patients, neither treatment completely eradicated the syphilis micro-organism from the blood or cerebrospinal fluid.

Evaluation, Penicillin G, Amoxicillin, Probenecid

---

Macrolide resistance in Treponema pallidum in the United States and Ireland

Article Abstract:

Azithromysin is found to be effective in the treatment of Syphilis along with penicillin, which is used for decades. Research reveals that in certain geographic regions, macrolide resistance in a strain of Treponema pallidum is relatively high, so prescribing azithromycin should be avoided.

Science & research, Research, Macrolide antibiotics, Macrolides, Dosage and administration, Treponema pallidum

Similar abstracts:

• Abstracts: Efficacy of aerosolized tobramycin in patients with cystic fibrosis. Management of pulmonary disease in patients with cystic fibrosis
• Abstracts: Quantification of ovarian stromal Doppler signals in poor responders undergoing in vitro fertilization with three-dimensional power Doppler ultrasonography
• Abstracts: Elevation of granulocyte-macrophage colony-stimulating factor in the placenta and blood in preeclampsia. Altered monocyte function in experimental preeclampsia in the rat
• Abstracts: Mark Mattson. Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome
• Abstracts: Direct comparison of the acute in vivo effects of HIV protease inhibitors on peripheral glucose disposal. Transport of HIV protease inhibitors through the blood-brain barrier and interactions with the efflux proteins, P-glycoprotein and multidrug resistance proteins

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.