Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues
Article Abstract:
This article details the usefulness of imaging mass spectrometry technology to map and image biomolecules within mammalian tissues. Matrix-assisted laser desorption/ionization mass spectrometry has been used to develop this technology, and it can be used to analyze proteins and peptides on or close to the surface of tissue samples.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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Tumor-specific gene expression in hepatic metastases by a replication-activated adenovirus vector
Article Abstract:
Adenovirus vectors have shown transgene expression in every metastasis examined, while no transgene induction was observed outside tumors. This research has provided a new concept for gene expression specific to tumors that can also be applied to conditionally replicating adenovirus vectors.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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Regulation of Fas ligand expression and cell death by apoptosis-linked gene 4
Article Abstract:
ALG-4F, a truncated transcript that prevents T cell-receptor-induced FAS/Fas ligand (FasL) upregulation and cell death in studies of apoptosis induced by T cell-receptor engagement. Study results show ALG-4 is likely necessary and sufficient for FasL expression.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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