Impaired prostate tumorigenesis in EGr1-deficient mice
Article Abstract:
Research presented concerns the relationship between the overexpression of early growth response protein 1 (EGR1) and human prostate cancer. The impact of Egr1 deficiency on tumorigenesis is discussed, as well as Egr1's role in regulating the development from prostatic intra-epithelial neoplasia to invasive carcinoma.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia
Article Abstract:
The functions of Nor-1 and Nur77 as critical tumor suppressors of myeloid leukemogenesis which might provide potential targets for therapeutic intervention of acute myeloid leukemia (AML) are described.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis
Article Abstract:
Nicotine clearly induces angiogenesis, accelerates tumor growth, and promotes atherosclerosis. These effects are mediated by nocotinic acetylcholine receptors at significantly high concentrations.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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- Abstracts: The humoral side of insulin resistance. AML1-ETO downregulates the granulocytic differentiation factor C/EBP(alpha) in t(8;21) myeloid leukemia
- Abstracts: Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia. The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling