Incidence and Clinical Course of Thrombotic Thrombocytopenic Purpura Due to Ticlopidine Following Coronary Stenting
Article Abstract:
The anticoagulant drug ticlopidine can cause thrombotic thrombocytopenic purpura (TTP), which can be fatal if not treated. Ticlopidine is often given to patients who are receiving a stent, which is a small cylindrical device inserted into blocked arteries to keep them open. During a one-year period, 19 patients who received ticlopidine developed TTP, which is characterized by anemia, low blood platelet counts and bleeding into the skin. This is an incidence of 1 case of TTP for every 4,814 patients treated, or 0.02%. This is much higher than the 0.0004% incidence of TTP in the general population. Four patients died but none of the 13 who received plasmapheresis died.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: A randomized trial
Article Abstract:
A study is conducted to determine the effect of an inhibitor of 5-lipoxygenase-activating protein (FLAP) on levels of biomarkers associated with myocardial infarction (MI) risk. It is concluded that in patients with specific at-risk variants of 2 genes in the leukotriene pathway, DG-031 led to significant and dose-dependent suppression of biomarkers that are associated with increased risk of MI events.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
The Genomics gold rush
Article Abstract:
Human genetic studies have assumed a totally new look with high-throughput genotyping and such genome-wide association studies are very helpful in the detection of most ailments.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Thrombotic thrombocytopenic purpura. AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP
- Abstracts: The clinical efficacy of oral tocolytic therapy. Prior cone biopsy: Prediction of preterm birth by cervical ultrasound
- Abstracts: Build upon strengths and leadership practices using EBP. Developing an integrated falls prevention strategy
- Abstracts: NICE launches new guidelines on managing stress urinary incontinence. Urinary incontinence in women
- Abstracts: New NICE guidance on the secondary prevention of MI. Guidance on treating urinary tract infection in children