Increased dose of lopinavir/ritonavir compensates for efavirenz-induced drug-drug interaction in HIV-1-infected children
Article Abstract:
An investigation of the pharmacokinetics of increased-dose lopinavir and ritonavir with normal-dose efavirenz in HIV-1-infected children is presented. The results revealed that the increased dose of 300/75 mg/m(super 2) twice-daily lopinavir and ritonavir compensates for the enzyme-inducing effect of efavirenz in HIV-infected children.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2005
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Pharmacokinetics of indinavir/ritonavir (800/100mg) in combination with efavirenz ({600mg) in HIV-1-infected subjects
Article Abstract:
Efavirenz (600mg) is added to indinavir/ritonavir (800/100mg) results in significant decreases in indinavir levels in healthy volunteers. The combination of indinavir/ritonavir (800/100mg) bid and efavirenz at 600mg results in adequate minimum concentrations of both indinavir and efavirenz for treating native patients.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2003
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Plasma HIV-1 RNA decline within the first two weeks of treatment is comparable for nevirapine, efavirenz, or both drugs combined and is not predictive of long-term virologic efficacy: A 2NN substudy
Article Abstract:
An interim analysis based on the data from the first 400 patients to assess possible differences in plasma HIV-1RNA (pVL) decline between the treatment groups is presented. A similar rate of initial decline of pVL for nevirapine (NVP), efavirenz (EFV), and NVP + EFV after adjusting for baseline pVL and region is shown.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2005
User Contributions:
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