Inflammatory bowel disease genetics: Nod2
Article Abstract:
The inflammatory bowel diseases (IBD) are constituted of two major subphenotypes, that is Crohn's disease (CD) and ulcerative colitis (UC). Lately, the association of Nod2 (CARD15) polymorphisms with CD was established, and taken together, the Nod2 association to CD provides an illustrative model of the role of the single gene variants in disease pathogenesis for common, complex multigene disorders. General features of IBD genetics with particular focus on the role of Nod2 in CD, are reviewed.
Publication Name: Annual Review of Medicine
Subject: Health
ISSN: 0066-4219
Year: 2007
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Inducing intestinal growth
Article Abstract:
New approaches to the treatment of intestinal and epithelium-related disorders are described. Scientists discovered that R-spondin1, a newly identified human protein, activates beta-catenin signaling and dramatically increases the proliferation and growth of the small and large intestines in mice.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2005
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Bugging of the intestinal mucosa
Article Abstract:
The Escherichia coli bacteria present in the intestines of patients with Crohn's disease causing an inflammatory bowel disease is presented.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2007
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