Initiation of antiretroviral therapy during recent HIV-1 infection results in lower residual viral reservoirs
Article Abstract:
Around 39 HIV-1 infected subjects were quantified for HIV-1 DNA in peripheral blood samples, 26 patients initiated non-nucleoside reverse transcriptase inhibitor (NNRTI) based based antiretroviral therapy (ART) at two different stages of infection, 16 during recent infection (RI) and 10 during chronic infection. The data indicates that initiation of NNRTI ART during recent HIV-1 infection reduces HIV-1 DNA to levels comparable to those seen in long-term non-progressors.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2004
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HIV-2-infected individuals with undetectable plasma viremia carry replication-competent virus in peripheral blood lymphocytes
Article Abstract:
Infectious HIV-2 variants were isolated from 6 HIV-2-infected individuals having undetectable plasma viremia and maintained high CD4(super +) T-cell numbers for prolonged periods, by use of optimized HIV co-culture protocol. The frequency of peripheral blood mononuclear cells (PBMCs) with infectious virus was low, ranging from 0.01-0.9 infectious units per million (IUPM) CD4(super +) T cells with a median value of 0.2 IUPM.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2004
User Contributions:
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alpha-Defensins released into stimulated CD8plus T-cell supernatants are likely derived from residual granulocytes within the irradiated allogeneic peripheral blood mononuclear cells used as feeders
Article Abstract:
The subpopulation of CD8+ T-cells supernatants that produce alpha-defensins are most likely derived from residual granulocytes within the irradiated allogenic peripheral blood mononuclear cells (PBMC). The newly found data mention the absence or a limited quantity of a CD8+ T-cells derived from noncytolytic anti-HIV-1 factor, other than beta-chemokines, under experimental conditions.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2004
User Contributions:
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