Insulin-like growth factors and cancer
Article Abstract:
Insulin-like growth factors (IGFs) may play a role in the growth and spread of cancer. IGFs are a family of peptides, receptors, and binding proteins that stimulate and regulate normal growth and development. Some are made in the liver and reach their target cells via the circulatory system. Others are produced and used locally. Some have general functions; others affect specific target tissues. Studies of cell growth indicate that certain IGFs play a pivotal role both in normal cell growth and cancerous growth stimulated by cancer-causing viruses. Studies of breast cancer, rhabdomyosarcoma (skeletal muscle cancer), osteosarcoma (bone cancer), and Wilms tumor (kidney cancer) also show that IGFs appear to play a role in cancerous growth. It may be possible to develop new therapies for treating cancer by interfering with the IGF system.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1995
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Non-insulin-dependent diabetes mellitus in minorities in the United States
Article Abstract:
Minority populations appear to be at greater risk for developing non-insulin-dependent diabetes mellitus and its most severe debilitating effects than white persons in the US. Studies performed between 1976 and 1994 have found that minority populations including Hispanic, black, Pacific Islander, Native American, Asian, but not Alaskan natives are two to six times more likely to develop non-insulin-dependent diabetes mellitus than white persons. Eye and nerve damage is more common and more diabetes-associated amputations are performed among many of these populations.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1996
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Use of common laboratory tests to identify people with insulin resistance
Article Abstract:
The best blood tests for identifying overweight people who may have insulin resistance are triglyceride level, ratio of triglyceride to HDL cholesterol, and insulin level, according to a study of 258 overweight people. Insulin resistance means the body produces greater than normal amounts of insulin to control blood sugar. It is considered an early sign of type 2 diabetes.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 2003
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