Intra-articular pressure changes in rheumatoid and normal peripheral joints
Article Abstract:
Elevated intra-articular pressure (IAP) in resting joint fluid may indicate the presence of joint inflammation and possible joint disease. IAP is the pressure that the joint fluid exerts within the joint cavity space. Researchers measured resting and exercise IAP levels in reference to atmospheric pressure in the finger, ankle, wrist, and elbow joints of 20 patients with rheumatoid arthritis (RA) and 15 healthy volunteers. All of the patients with RA had resting and IAP levels above atmospheric pressure. Exercise produced more than a four-fold increase in IAP for patients with RA. Resting IAP levels of the healthy volunteers were below atmospheric pressure and did not change with exercise. A saline injection into the joints of the healthy volunteers to simulate RA produced resting and exercise IAP levels approaching the IAP levels of the RA patients.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1995
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Influence of hypoxia in inflammatory synovitis
Article Abstract:
Inflammatory synovitis in rheumatoid arthritic joints may result from chronic oxygen deprivation. Increased acidity, lactate, and carbon dioxide and reduced glucose in inflamed joints suggests that cells are hypoxic and using glycolytic metabolism for energy. Synovial membranes in rheumatoid joints are also deficient in blood supply, aggravating the hypoxic state. Research with bioreductive drugs, which metabolize to toxic molecules in oxygen-deficient cells, may improve rheumatoid arthritis care.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1998
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Tumour necrosis factor alpha stimulated rheumatoid synovial microvascular endothelial cells exhibit increased shear rate dependent leucocyte adhesion in vitro
Article Abstract:
The authors investigated and identified various levels of cell adhesion in rheumatoid arthritic synovial tissue. They describe how endothelial cells regulate other tissues in that condition.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1999
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