Intrauterine endoscopic creation of urinary tract obstruction in the fetal lamb: a model for fetal surgery

Article Abstract:

Endoscopic surgery may be used to successfully correct defects in the fetus still in the womb, as demonstrated in lamb fetuses. Researchers performed endoscopic surgery on 21 lamb fetuses to first create urinary tract obstructions and then to correct them. Fetal bleeding was minimal and did not make it too difficult for surgeons to see. The overall survival rate after surgery was 76%. The group of older lamb fetuses, correlating to human fetuses in the middle of the second trimester, had a lower mortality rate than did young fetuses, correlating to human fetuses in the early third trimester. The mortality rate of 38% for young fetuses is lower than than of open surgery, where fetuses are taken outside of the womb.

Fetus, Surgery, Fetal surgery, Urinary organs, Urologic diseases

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Fetal lung-to-head ratio in the prediction of survival in severe left-sided diaphragmatic hernia treated by fetal endoscopic tracheal occlusion (FETO)

Article Abstract:

The value of the fetal lung area to head circumference ratio in the prediction of the postnatal outcome in left-sided congenital diaphragmatic hernia treated by fetoscopic endoluminal tracheal occlusion is investigated. It is concluded that postnatal survival can be predicted by the lung area to head circumference ratio measured prior to the procedure in congenital diaphragmatic hernia treated by c.

United States, Care and treatment, Physiological aspects, Infants (Newborn), Newborn infants, Postnatal care, Diaphragm, Diaphragmatic hernia

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Effect of tracheal occlusion on peripheric pulmonary vessel muscularization in a fetal rabbit model for congenital diaphragmatic hernia

Article Abstract:

The study was undertaken to evaluate the effects on peripheric pulmonary vessel muscularization by tracheal occlusion (TO) performed at different gestational ages in fetal rabbits with surgically induced diaphragmatic hernia. In a rabbit model it was demonstrated that in utero, TO can prevent typical vascular structural changes related to diaphragmatic hernia.

Science & research, Research, Diagnosis, Risk factors, Rabbits, Pulmonary alveoli, Tracheal diseases

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