Involvement of simultaneous multiple transcription factor expression, including cAMP responsive element binding protein and OCT-1, for synovial cell outgrowth in patients with rheumatoid arthritis
Article Abstract:
Simultaneous expression of several gene transcription factors may be associated with the inflammatory and destructive changes of rheumatoid arthritis. Rheumatoid arthritis is an autoimmune inflammatory joint disease. Researchers used immunohistochemistry to analyse synovial tissue from patients with rheumatoid arthritis and found that gene transcription factors were simultaneously expressed in overgrown joint tissues. Simultaneous expression of multiple genes related to tissue development may underlie the progressive joint disease.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
Antisense oligonucleotides targeting c-fos mRNA inhibit rheumatoid synovial fibroblast proliferation
Article Abstract:
Antisense oligonucleotides may inhibit genetic activity which promotes the overgrowth of synovial tissue in rheumatoid arthritis. Researchers tested this form of gene therapy in samples of synovium from rheumatoid arthritic joints. Specific oligodeoxynucleotides appeared to block expression of a gene thought to be associated with the growth of synovial fibroblast cells. Fibroblast proliferation was inhibited in the genetically transfected tissue. This may form the basis of an effective therapy for rheumatoid arthritis.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
Synovial membrane p53 protein immunoreactivity in rheumatoid arthritis patients
Article Abstract:
Levels of the p53 protein are not increased in the synovial membranes of patients with rheumatoid arthritis. This indicates that the normal protein exists in these patients, not the abnormal form. The abnormal form causes cell proliferation and was believed to be involved in the development of rheumatoid arthritis.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Influence of sulphasalazine, methotrexate, and the combination of both on plasma homocysteine concentrations in patients with rheumatoid arthritis
- Abstracts: Cytokine and adhesion molecule expression in the minor salivary glands of patients with Sjogren's syndrome and chronic sialoadenitis
- Abstracts: Acute myocardial infarction - the value of being prepared. An association between collateral blood flow and myocardial viability in patients with recent myocardial infarction
- Abstracts: Relationship between overnight energy expenditure and BMR measured in a room-sized calorimeter. Total daily energy expenditure and pattern of physical activity measured by minute-by-minute heart rate monitoring in 14-15 year old Swedish adolescents
- Abstracts: General internal medicine. Percutaneous Electrical Nerve Stimulation for Low Back Pain: A Randomized Crossover Study