Isolation and transduction of CD34+ cells from small quantities of peripheral blood from HIV-1-infected patients not treated with hemopoietic growth factors
Article Abstract:
It may be possible to isolate CD34+ T cells from the blood of HIV patients without giving them hemopoietic growth factors. These growth factors are used to boost the production of T cells. Researchers measured the amount of CD34+ T cells in blood samples from HIV-negative volunteers and HIV-positive patients, some of whom received growth factors and some of whom did not. Although the HIV-positive patients not taking growth factors had lower levels of T cells than the HIV-negative volunteers, the number of cells was still adequate. The cells will be used to administer gene therapy to HIV patients.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1999
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Active movement of T cells away from a chemokine
Article Abstract:
Researchers show that T cells can move away from a stimulus just as neurons, prokaryotes, and simple eukaryotes. High concentrations of the chemokine stromal cell derived factor-1 repelled T cells, a movement that was inhibited by antibody against the CXCR4 receptor.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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The lysophosphatidic acid receptor [LPA.sub.1] links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak
Article Abstract:
The function of the lysophosphatidic acid receptor [LPA.sub.1] in mediating fibroblast recruitment and vascular leak that allows lung injury to lead to pulmonary fibrosis is discussed.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2008
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