Lack of influence of non-inherited maternal HLA-DR alleles on susceptibility to rheumatoid arthritis
Article Abstract:
Non-inherited maternal HLA-DR alleles may not increase susceptibility to rheumatoid arthritis (RA). The HLA-DR bands on human chromosomes have been associated in some studies to be related to maternal transfer as well as paternal transfer of a genetic risk factor for RA. In a study of families from a registry of RA patients, non-inherited maternal antigens (NIMA) from DR genes and non-inherited paternal antigens (NIPA) from DR genes were compared on DNA from 74 rheumatoid factor positive individuals from 39 families with more than one member with RA and their first-degree relatives. There was no increase in frequency of NIMA DR varieties of genes when compared with NIPA DR gene varieties. Since there are plausible arguments for these findings which do not exclude the hypotheses concerning both parents contribution to RA susceptibility, further research needs to be done.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1995
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Absence of an association between HLA-DRB1*04 and rheumatoid arthritis in newly diagnosed cases from the community
Article Abstract:
Individuals with the gene for HLA-DR4 may not have a higher risk of developing rheumatoid arthritis (RA) than those without. HLA-DR4 is one type of histocompatibility antigen. Among 208 patients who had genetic analysis for the genes for HLA-DR1 and HLA-DR4, 89 had been recently diagnosed with RA and 119 had inflammatory polyarthritis (control group). Forty-two percent of the RA patients had the gene for HLA-DR4, compared to 37% of the patients in the control group. Eighteen percent of the RA patients had the gene for HLA-DR1, compared with 25% of the patients with inflammatory polyarthritis. The gene for HLA-DR4 may be more predictive of disease severity and persistence in RA patients.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1993
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Linkage of cytokine genes to rheumatoid arthritis. Evidence of genetic heterogeneity
Article Abstract:
Three genes which code for the production of cytokines appear to be related to the development of rheumatoid arthritis. Cytokines are proteins released by cells of the immune system which induce responses in other cells. Researchers analyzed the genes of 200 pairs of siblings affected by rheumatoid arthritis. The autoimmune inflammatory joint disease was associated with genes which code for interleukin 5R, interferon gamma, and interleukin 2. These cytokines are known to mediate inflammatory processes in joints. Rheumatoid arthritis may be associated with several genes.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1998
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