Leiomyosarcomas: clinical presentation

Article Abstract:

Leiomyosarcoma of the uterus is a rare form of cancer comprising about 1.3% of all uterine cancers. Benign leiomyomas, which are tumors in the smooth muscle of the uterus, outnumber malignant leiomyomas by 800 to one, but distinguishing between the two is difficult. Following more conservative treatments such as close observation, gonadotropin-releasing hormone therapy and tumor removal may spare fertility and prevent unnecessary hysterectomy. Of 21 women aged 30 to 83 diagnosed with leiomyosarcoma, 13 had vaginal bleeding, four had pelvic pain, 11 had a pelvic mass and four had a rapidly expanding uterus. Cancer sites within the uterus varied among the women, and tumors varied in shape. The leiomyosarcoma was confined to one uterine mass in 19 of the women. Ten of them had previously had a tumor removed from their breast, six of which were malignant.

Care and treatment, Uterine cancer, Leiomyoma, Leiomyosarcoma

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First-trimester Doppler investigation of the uterine circulation

Article Abstract:

The accomplishments of Doppler ultrasonography of the uterine artery and its terminal branches in investigating the physiologic changes of normal pregnancy and pathophysiologic alterations of complicated pregnancies during the first trimester are described. Doppler evaluation of first trimester pregnancy is dependent on the knowledge of the normal placentation process. Pharmacologic compounds can transiently change uterine Doppler velocimetry characteristics in vivo, but no long-term follow-up is currently available.

Usage, Diagnosis, Uterus, Pregnancy, Complications of, Pregnancy complications, Doppler ultrasonography, Uterine circulation

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Regulation of expression of tissue plasminogen activator and plasminogen activator inhibitor-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions

Article Abstract:

Stimulation of aerobic metabolism would alter differential expression of tissue plasminogen activator and plasminogen activator inhibitor-1 creating a milieu likely to be less favorable to postoperative adhesion development. The result reveals that normal peritoneal fibroblasts under hypoxic conditions, and in adhesion fibroblasts under normoxic and hypoxic conditions, dichloroacetic acid greatly increased in the tissue plasminogen activator inhibitor-1.

United States, Science & research, Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Blood Clot Dissolvers, Research, Tissue plasminogen activator, Fibrinolytic agents, Postoperative care, Thrombolytic drugs

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