Long-term outcome of Haemophilus influenzae meningitis in Navajo Indian children

Article Abstract:

Navajo children who survive Haemophilus influenzae (Hib) meningitis appear likely to experience permanent brain damage. Researchers evaluated neurologic functioning in 41 Navajo children who had Hib meningitis at age 5 or younger. Results were compared with the nearest sibling or half-sibling in age and with a group of children of the same age and sex living in the same area. The meningitis group had an average IQ of 79 versus 87 among siblings, and 95 among the age-matched group. Twenty-four percent were mentally retarded versus 8% of siblings and 2% of the age-matched group. Two in the meningitis group were profoundly deaf, three had cerebral palsy, and five had recurrent seizures versus none in the other groups. However, similar percentages of children in the meningitis group and their siblings were in special education classes versus none of the age-matched controls. Data suggest that deficits in the meningitis group may partly be due to socioeconomic factors.

Complications and side effects, Pediatric diseases, Meningitis, Navajos, Hemophilus infections

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Clinical and Economic Impact of a Combination Haemophilus influenzae and Hepatitis B Vaccine

Article Abstract:

The replacement of the haemophilus influenzae type b (Hib) vaccine with a combination hepatitis B (HBV)-Hib vaccine in children could significantly reduce the risk of HBV infection. HBV vaccination is recommended for all infants, but only about 75% of children receive the injections. Parents may desire to minimize the number of pediatrician visits and injections their children require, and HBV vaccination requires three injections. Researchers compared the costs and benefits of separate injections with a combination vaccine for both diseases. For an additional $7 per child, the combination vaccine would increase HBV vaccination rates and prevent approximately 40,000 cases of hepatitis B in children.

United States, Methods, Evaluation, Product/Service Evaluation, Children, Vaccination of children, Vaccination, Hepatitis B vaccine, Hepatitis B vaccines, Hib vaccines, Comvax (Medication)

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Risk of bacteremia for febrile young children in the post-Haemophilus influenzae type b era

Article Abstract:

The rate of asymptomatic bacteria in the blood among children between 3 months and 36 months of age seems to be lower than expected. It had been generally supposed the rate would be about 3% to 5% of those with a fever, of which about 10% would have serious infections. A total of 9,465 children who had been vaccinated with Haemophilus influenza type b vaccine and who had a temperature of 39.0 C were tested. Of these, about 1.6% were found to have bacterial infection, primarily pneumococcal.

Diagnosis, Fever in children, Childhood fever, Bacteremia

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