Mutational analysis of the PTEN gene in human uterine sarcomas

Article Abstract:

Mutations of the PTEN gene do not cause all uterine sarcomas, according to a study that only found a PTEN mutation in two out of 36 tissue samples from women with uterine sarcoma. This type of uterine cancer is rare, making up 5% of all uterine cancers.

Uterine cancer, Sarcoma

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Loss of heterozygosity on chromosome 17q11-21 in cancer of women who have both breast and ovarian cancer

Article Abstract:

Inherited abnormalities of the BRCA1 gene appear to be involved in some cases where women develop both breast and ovarian cancer independently. The BRCA1 gene is believed to be an important tumor suppressor gene, but at the time of this investigation, its chromosome was known, but not its precise location. Only indirect investigation of abnormalities within regions of its chromosome could be carried out. Its location has since been pinpointed. Cancerous and normal tissue samples were analyzed from 29 women who developed primary cancers of both breast and ovary. DNA analysis revealed abnormalities of the chromosome containing BRCA1 in 46% of breast cancers, 78% of ovarian cancers, and 38% of both cancers. In all cases where the chromosome was abnormal in both cancers, the same strand of the pair was affected. These cases also tended to be among younger women. These women seem more likely to have an inherited genetic defect.

Breast cancer

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Role of BRCA1 mutation screening in the management of familial ovarian cancer

Article Abstract:

A screening test to identify the altered gene thought to be responsible for breast and ovarian cancer is now available. This gene is called the BRCA1 susceptibility gene. Research has shown that more than 90% of the women with ovarian cancer who have an immediate family history of ovarian cancer carry the BRCA1 gene. It may be advisable for women who carry this gene to have their ovaries removed as a preventive measure. However, research has not yet identified the best possible course of action for these carriers.

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