Breast cancer after prophylactic bilateral mastectomy in women with a BRCA1 or BRCA2 mutation

Article Abstract:

Women with a BRCA1 or BRCA2 gene mutation can reduce their risk of breast cancer by having both breasts surgically removed. In a study of 139 such women, none of the 76 who had a bilateral prophylactic mastectomy developed cancer over an average of three years compared to 8 of the 63 women who did not have a mastectomy.

Health aspects, Gene mutations, Gene mutation

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Prophylactic mastectomy for women with BRCA1 and BRCA2 mutations -- facts and controversy

Article Abstract:

Women with mutations in the BRCA1 or BRCA2 gene that increase their risk of breast cancer can reduce this risk by having both breasts surgically removed. Those who are not willing to do this could take tamoxifen and have regular mammograms that include MRI imaging.

Editorial, Usage

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Efficacy of bilateral prophylactic mastectomy in women with a family history of breast cancer

Article Abstract:

Prophylactic mastectomy may significantly reduce the risk of breast cancer in women with a strong family history of the disease. During a prophylactic mastectomy, surgeons remove a woman's breasts even though she does not actually have breast cancer. Between 1960 and 1993, 639 women with a family history of breast cancer had a prophylactic mastectomy at the Mayo Clinic. An estimated 37 women should have developed breast cancer, but only four did. Among the 403 sisters of women at high risk, 39% developed breast cancer, but only 1.4% of the women who had a mastectomy developed cancer.

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