Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice
Article Abstract:
Investigations were carried out to show that deletion of the Von Hippel-Lindau gene (Vhlh) from intrinsic glomerular cells leads to stabilization of hypoxia-inducible factor subunits (HIFs) and the de novo expression of Cxcr4 was identified using gene profiling expression. The course of rapidly progressive glomerulonephritis was significantly improved in mice treated with a blocking antibody to Cxcr4, whereas overexpression of Cxcr4 alone in podocytes of transgenic mice caused glomerular disease.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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AML-1 steps up to the platelets
Article Abstract:
Conditional removal of the putative tumor suppressor gene Acute Myeloid Leukamia-1 (AML-1) encoded by the runt-related X1gene, (RUNX1) from the bone marrow of mice mimics a human familial platelet disorder. Details of the AML-1 and RUNX1 are discussed in detail.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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Fragile fugue: p53 in aging, cancer and IGF signaling
Article Abstract:
Aging is driven partly by an evolutionarily conserved hormone signaling pathway. A new study shows that the p53 tumor suppressor, which balances the need for cell proliferation against that for tumor suppression exquisitely, controls this pathway.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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