Lymphocytic enterocolitis in patients with "refractory sprue" (celiac disease unresponsive to treatment)
Article Abstract:
Celiac disease or sprue is a malabsorption syndrome caused by a patient's inability to eat gluten. In the past 20 years many clinical reports have shown the association of abnormal biopsy of the colorectal region (junction of colon and rectum) with celiac disease. The nature and significance of these pathologies have not been determined, however. The colorectal biopsy of 21 patients identified as having celiac disease were examined. Of this group, seven of the biopsies were classified as abnormal. Three of the patients with histologic abnormalities had an infiltration of specific white blood cells within the biopsy specimens and failed to respond to a gluten-free diet. The patients with 'refractory sprue' may represent a different illness for which the term lymphocytic enterocolitis is suggested.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1989
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Genetic testing in hereditary colorectal cancer
Article Abstract:
Genetic tests exist for the two types of hereditary colorectal cancer but patients must be properly counseled to benefit from them. Familial adenomatous polyposis is characterized by the formation of over 100 polyps in the colon. It accounts for only 1% of all colorectal cancer, but occurs at an early age and can be fatal if untreated. It is caused by a mutation in the APC gene and there is a test for this. Hereditary nonpolyposis colorectal cancer (HNPCC) consists of only one tumor, but it is caused by one of four genes and tests are available for only two.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1997
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Effect of neurolytic celiac plexus block on pain relief, quality of life, and survival in patients with unresectable pancreatic cancer: a randomized
Article Abstract:
Pancreatic cancer is an aggressive tumor associated with high mortality. Double blind randomized clinical trial showed that although NCPB (neurolytic celiac plexus block) improves pain relief in patients with pancreatic cancer vs. optimized analgesic therapy alone, it does not affect the quality of life or survival.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2004
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