MGMT gene silencing and benefit from temozolomide in glioblastoma

Article Abstract:

The relationship between MGMT (O(super 6)-methylguanine-DNA methyltransferase) silencing in the tumor and the survival of patients, who were enrolled in a randomized trial comparing radiotherapy alone with radiotherapy combined with concomitant and adjuvant treatment with temozolomide, is tested. It was found that the patients with glioblastoma containing a methylated MGMT promoter benefited from temozolomide, whereas those who did not have a methylated MGMT promoter did not have such a benefit.

United Kingdom, Science & research, Care and treatment, Usage, Diagnosis, Glioblastoma multiforme, Gene silencing, Temozolomide

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Blood lead concentration and delayed puberty in girls

Article Abstract:

Lead in the body may delay puberty in some girls, especially African-American and Mexican-American girls. This was the conclusion of a study of 2,186 girls. Blood levels as low as three micrograms per deciliter were associated with delays in breast development and pubic hair growth. In African-American girls with this blood lead level, puberty was delayed by an average of four months compared with girls with lower lead levels.

Health aspects, Causes of, Environmental aspects, Growth disorders, Puberty, Lead poisoning, Delayed puberty

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