Medical eligibility, comprehension of the consent process, and retention of injection drug users recruited for an HIV vaccine trial

Article Abstract:

Injection drug users (IDUs) appear to be generally eligible for trials of HIV vaccines, because they tend to understand the informed consent process and keep their follow-up appointments. Researchers administering a trial of HIV vaccines evaluated volunteers' eligibility based on medical condition and performance on a 17 question true-false test on the informed consent trial. Common reasons for exclusion of IDUs involved medical problems, including HIV infection, tuberculosis infection, and anemia. Three IDUs were ineligible because of their performance on the comprehension test. The average score on the test was 15.4 among eligible IDUs and 15.9 among eligible non-IDUs. Participation in follow-up was similar between IDUs and non-IDUs. IDUs should not be assumed ineligible for participation in such trials.

Drug addicts, Drug abusers

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Strategies for addressing the social and behavioral challenges of prophylactic HIV vaccine trials

Article Abstract:

Researchers who plan to use human volunteers in HIV vaccine trials may need to address the behaviors and social environment that put these people at risk for acquiring HIV. The National Institutes of Health has teamed with several research communities that have already enlisted groups of volunteers. Volunteers should be informed that participation in a trial will not give them personal protection from HIV. Ideally, volunteers will have a desire to increase researchers' understanding of HIV. People at high risk for acquiring HIV and who perceive their risk to be high may be the best group of volunteers for vaccine efficacy trials. Volunteers' risk behaviors should be assessed, and counseling on how to lower risk behaviors should be offered if needed.

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Incentives and disincentives to participate in prophylactic HIV vaccine research

Article Abstract:

Researchers who plan to conduct large studies on HIV vaccines may need to address the concerns of their human volunteers. Results of a survey in Thailand of 255 people who might be considered for participation in a vaccine trial showed that most people did not want to be involved in such a trial. Many people feared social discrimination from being associated with an HIV vaccine trial. Social discrimination may be especially prevalent in Thailand, and therefore a real concern for all associated with the trial. In Thailand, the disadvantages of being associated with an HIV vaccine trial may outweigh any incentives. Researchers may need to gain the trust of volunteers and provide attractive incentives for participation.

Beliefs, opinions and attitudes, Thais

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