Metformin for non-insulin-dependent diabetes mellitus

Article Abstract:

Metformin is a useful oral drug for treating high blood-sugar in patients with non-insulin-dependent diabetes mellitus (NIDDM) that cannot be controlled by diet. Metformin works by enhancing the transfer of glucose out of the blood while decreasing the production of glucose by the liver. In a trial of 2520 NIDDM patients, it was found that diet along with metformin or another drug was a more effective treatment than diet alone. Metformin has negative side effects on the digestive system, including nausea, vomiting, diarrhea, and anorexia. It also can cause the build-up of lactic acid in patients whose kidneys are not functioning properly. Metformin's 30-day minimum dosage cost is $47.50 to the pharmacist. It is sold under the brand name Glucophage. The usual dosage is 850 mg twice a day.

Health aspects, Hypoglycemic agents, Glucophage (Medication)

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Troglitazone for non-insulin-dependent diabetes mellitus

Article Abstract:

Troglitazone is an oral drug used to treat type 2, or adult onset, diabetes. Sold under the trade name Rezulin, its primary action is to decrease insulin resistance. Consequently, it is usually used in combination with insulin. It also lowers blood sugar levels, but not as much as other drugs such as metformin or sulfonylureas. It has some side effects and may interact with cholestyramine oral contraceptives and terfenadine.

Rezulin (Medication), Troglitazone

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Glyburide/metformin (Glucovance) for type 2 diabetes

Article Abstract:

The US FDA has approved Glucovance, which contains glyburide and metformin in one pill for the treatment of type 2, or adult onset, diabetes. Glyburide increases insulin secretion and metformin makes the liver and muscles more sensitive to insulin. Glucovance is less expensive than both drugs separately.

Glucovance (Medication)

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