Methotrexate pharmacokinetics and effects in women receiving methotrexate 50 mg and 60 mg per square meter for early abortion

Article Abstract:

Methotrexate may be effective and nontoxic in higher doses than normally used for the induction of early abortion. Researchers evaluated the safety and effectiveness of two different doses of methotrexate injection in 20 women seeking abortion. Ninety percent of women receiving 50 milligrams per square meter (mg/m2) aborted their pregnancies, and all women aborted who had received 60 mg/m2. The drug was not detected in the blood within 48 to 72 hours after treatment, nor did it reach sustained toxic levels. Similar rates of drug clearance have been reported in nonpregnant women.

Health aspects, Research, Methods, Methotrexate, Pharmacokinetics, Abortion, Therapeutic, Therapeutic abortion

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The roles of clinical assessment, human chorionic gonadotropin assays, and ultrasonography in medical abortion practice

Article Abstract:

Methods for diagnosing pregnancy in the very early stages are discussed. This is important when using drugs that terminate pregnancy because they are less effective as pregnancy advances.

Services, Diagnosis, Pregnancy, Abortion, Pregnancy diagnosis

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Similar abstracts:

• Abstracts: A randomized trial comparing misoprostol three and seven days after methotrexate for early abortion

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