Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation
Article Abstract:
A study shows that deletion of the mouse gene encoding mitogen-inducible gene 6 (Mig6) causes hyperactivation of endogenous epidermal growth factor receptor (Egfr) and sustained signaling through the mitogen-activated protein kinase (MAPK) pathway, resulting in overproliferation and impaired differentiation of epidermal keratinocytes. Results indicate that Mig6 is a specific negative regulator of Egfr signaling in skin morphogenesis and is a novel tumor suppressor of Egfr-dependent carcinogenesis.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Savior and slayer: The two face of p53
Article Abstract:
A study to show that tumor suppressor protein, p53, can decrease the levels of intracellular reactive oxygen species to protect the genome from oxidative damage is presented. The study suggests that, in addition to responding to various types of stress, p53 has a proactive role during normal growth as the 'guardian of the genome'.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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