TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis

Article Abstract:

Studies were conducted to show that T cell-specific deletion of TRAF6 unexpectedly results in multiorgan inflammatory disease and that TRAF6-deficient T cells exhibit hyperactivation of the phosphatidylinositol 3-kinase_Akt pathway compared with wild-type T cells, and, as a result, become resistant to suppression by CD4+CD25+ regulatory cells. The results reveal the presence of a t-cell-intrinsic control mechanism to render responder T cells susceptible to tolerizing signals.

United States, Causes of, Genetic aspects, Inflammation, Tumor necrosis factor, Immune response, Tumour necrosis factor

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Homeostatic proliferation is a barrier to transplantation tolerance

Article Abstract:

Studies demonstrating the importance of alloreactive T-cell deletion during tolerance induction have promoted use of peritransplant T-cell depleting therapies in clinical trials. These findings establish the importance of homeostatic proliferation in clinically relevant settings.

Clinical trials

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Autoimmunity heats up

Article Abstract:

The factors that trigger development of autoimmunity are explained. The agents that cause breakdown of autoimmune system are also anticipated.

Autoimmunity

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