Modeling the emergence of the 'hot zones': tuberculosis and the amplification dynamics of drug resistance
Article Abstract:
'Hot zones' are areas that have less than 5 percent prevalence of multidrug tuberculosis (MDRTB) and hence a new mathematical model is presented to track the emergence and evolution of multiple strains of drug-resistant 'Mycobacterium tuberculosis'. It is essential to have an effective control on MDRTB in the hot zones and for doing so it is necessary that the World Health Organization (WHO) specify a goal for minimizing the amplification probability.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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Ascorbic acid treatment corrects the phenotype of a mouse model of Charcot-Marie-Tooth disease
Article Abstract:
A mouse model of Charcot-Marie-Tooth disease (CMT-1A) is used to test the ability of ascorbic acid, a promoter of mylenation, to correct the CMT-1A phenotype. Ascorbic acid treatment resulted in substantial amelioration of CMT-1A phenotype and thus offers an immediate form of therapeutic treatment of CMT disease.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
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