Molecular targets of gene transfer therapy for HIV infection
Article Abstract:
The feasibility of treating HIV infection with gene transfer therapy is currently being investigated. The strategy behind gene therapy is to transfer a gene into cells that are susceptible to infection to block the spread of HIV. Thus, gene transfer therapy would be used to treat people who are already infected with HIV, not to prevent HIV infection. There are potentially two broad techniques for intervention, and both involve using a vector to introduce the altered gene. Typically, a vector is an inactivated virus that contains the genetic information necessary to replicate as well as the altered gene but lacks the genetic information for specific viral proteins. Theoretically then, when the vector infects a target cell and is incorporated into the cell's DNA, so is the desired gene. The first technique involves introducing a gene that would eliminate HIV-infected cells. The second technique involves introducing a gene that would interfere with replication of HIV but would not kill the infected cell.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1993
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Strategies for Long-term Success in the Treatment of HIV Infection
Article Abstract:
People newly diagnosed with HIV infection should be treated as soon as possible and preferably by doctors with experience in treating HIV infection. Highly active antiretroviral therapy (HAART) has changed HIV infection from a rapidly fatal disease to a chronic but manageable one. Patients must be given drugs that they can reasonably take on a regular basis. Failure to comply with treatment can lead to drug resistance on the part of the virus. Patients with high blood levels of virus may still be relatively healthy.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2000
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Etiology of pruritic popular eruption with HIV infection in Uganda
Article Abstract:
Cross sectional study of HIV-infected patents with active pruritic papular eruption is conducted to determine the etiology of PPE occurring in HIV-infected individuals. Puritic papular eruption occurring in HIV-infected individuals may be a reaction to arthropod bites, which reflects an altered and exaggerated immune response to arthropod antigens in a subset of susceptible HIV-infected patients.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2004
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