Moricizine

Article Abstract:

Moricizine is a drug used to treat patients with life-threatening ventricular arrhythmia, or an irregular heart beat. Patients treated with moricizine often experience side effects. Moricizine may increase the risk of a heart attack or death in some patients. It may also increase the risk of congestive heart failure, especially in patients with a history of congestive heart failure. This drug affects the electrical properties of the heart, and slows down its activity. Patients are usually treated with 200 to 300 milligrams of moricizine every eight hours, and blood levels of the drug are highest one to two hours after receiving a dose. Moricizine may change the affect of other drugs in heart disease patients being treated with several drugs. The most serious side effects of moricizine are worsening of arrhythmias and heart failure. It can also cause nausea, dizziness and fever in some patients.

Arrhythmia

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Sudden death in young athletes

Article Abstract:

A sudden sharp blow over the heart may in rare cases stop the heart, causing death. Analysis of a series of cases found that a sharp blow over the heart such as may occur when being struck by a baseball or hockey puck can stop the heart. Death resulted even though there was no direct traumatic injury or apparent heart disease in the victim. Children appear to be particularly vulnerable because their chest wall is thin and more flexible than an adult's. One theory as to cause of death is that the shock disrupts the heart's electrical conduction and the heart goes into fibrillation. The fact that resuscitation efforts appear to be futile suggests there may be an alternate explanation. The phenomenon needs to be studied. Once the mechanism is understood, a study model can be developed and it should then become possible to test various means of preventing injury.

Editorial, Patient outcomes, Mortality, Causes of, Complications and side effects, Sudden death, Athletes, Blunt trauma

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Effect of the antiarrhythmic agent moricizine on survival after myocardial infarction

Article Abstract:

The antiarrhythmic drug moricizine may not be an effective or safe treatment for patients who have suffered a heart attack. Of 1,325 patients who suffered a heart attack, 665 were treated with moricizine and 660 received a placebo, an inactive substance, over a 14 day period. Among the patients treated with moricizine, 17 died from cardiac arrest or had a heart attack, compared with three patients treated with a placebo. Of 1,155 patients who were treated effectively with moricizine, 581 were treated over a long-term period with moricizine and 574 were treated with a placebo. Among the patients treated with moricizine, 49 died from cardiac arrest or had a heart attack, compared with 42 patients who received a placebo. More of the patients treated with moricizine had discontinued treatment at four months, compared with patients who received a placebo.

Heart attack

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