Neovascularisation and the induction of cell adhesion molecules in response to degradation products from orthopaedic implants
Article Abstract:
People who have had bone or joint implants may experience inflammatory reactions to the implant metals that may loosen the interface between bone and implant. The cellular interactions involved in the inflammatory process were analyzed in sections of tissue from the bone-implant interface obtained from 30 patients during surgery to correct a loosening artificial joint. The number and affinity of receptors for certain cell adhesion molecules were increased in response to the presence of metal wear debris. These molecules are responsible for recruiting immune cells to the site of an injury. Most of the tissue samples had been infiltrated by immune cells. The inflammation associated with noninfectious loosening of the bone-implant interface appears to be similar to that of joint inflammation.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1995
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Innervation of the synovium
Article Abstract:
Synovium is supplied by nerves, which may stimulate inflammation to protect the joint from injury or disease. Synovium is the membrane which lines the cavity of a joint. When rheumatoid arthritis degrades a joint, the synovium is constantly inflamed, and the nerve supply is abnormal. Substance P is a peptide which may stimulate the nerve fibers of the synovium to generate an inflammatory response to pain. It causes the weal and flare reaction marked by dilated veins and swelling. Substance P may also be involved in hypersensitivity reactions such as asthma. The synovium also contains enzymes that degrade peptides that signal nerves, such as substance P. Inflammation induced by substance P may actually serve to protect arthritic joints.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1995
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The function of tumour necrosis factor and receptors in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease
Article Abstract:
Research on tumor necrosis factor (TNF) and its role in several diseases is discussed. TNF is a protein produced by the body that causes inflammation. It is believed to be involved in the development of rheumatoid arthritis.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1999
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