Neurologic manifestations of AIDS: a comparative study of two populations from Mexico and the United States

Article Abstract:

There appear to be differences in the type and incidence of AIDS-related neurologic complications between developed and developing countries. Researchers evaluated neurologic complications in 40 Mexican and 130 U.S. AIDS patients between 22 and 67 years old. Twenty-six percent of the U.S. patients and 32.5% of the Mexican patients had some type of neurologic complication. AIDS dementia complex (ADC) was the most common neurologic complication in both groups. Almost 31% of the U.S. patients and 32.5% of the Mexican patients had ADC. Twenty percent of Mexican patients and 3.8% of U.S. patients had pulmonary tuberculosis. However, intracranial TB occurred only in the Mexican patients. Non-Hodgkin's brain lymphoma occurred in 8.4% of the U.S. patients and only 2.5% of the Mexican patients. These differences may reflect the use of more aggressive treatment and prophylaxis regimens in developed countries and the higher prevalence of endemic diseases in developing countries.

Health aspects, Complications and side effects, Demographic aspects, Developing countries, AIDS (Disease), Neurologic manifestations of general diseases, Neurologic manifestations

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High levels of anti-HIV-1 envelope antibodies in cerebrospinal fluid as compared to serum from patients with AIDS dementia complex

Article Abstract:

The detection of antibodies in cerebrospinal fluid (CSF) against the gp120 envelope protein of HIV could be a marker of AIDS dementia complex (ADC). ADC is a neurological disease that may be a direct result of viral infection of the brain, and the gp120 viral envelope protein has been implicated. Researchers measured levels of antibodies against the gp120 envelope protein in the blood and cerebrospinal fluid of 31 HIV-positive people, 21 of whom had ADC. All 31 participants had antibodies to gp120 in their blood, and all those who had ADC had antibodies in their CSF. Only half the people without ADC had CSF antibodies. In addition, antibody levels in blood and CSF were higher in HIV-positive people with ADC compared to those without. About one-fifth of those with moderate or severe ADC had higher CSF antibody levels than blood levels. This was not true in those with minimal ADC or those without ADC.

Analysis, Physiological aspects, Viral envelopes, Cerebrospinal fluid

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T-tropic sequence of the V3 loop is critical for HIV-1 infection of CXCR4-positive colonic HT-29 epithelial cells

Article Abstract:

The V3 domain of the HIV-1 gp120 envelope protein is necessary for the virus to infect intestinal cells. This allows the virus to use the CXCR4 receptor to enter the cells.

Infection, HIV infection, HIV infections, Epithelial cells

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