Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway
Article Abstract:
Neuromedin U (NMU) is a hypothalamic neuropeptide that regulates body weight and composition. An experiment shows that mice lacking the gene encoding NMU develop obesity. The results indicate that NMU plays an important role in the regulation of feeding behavior and energy metabolism independent of the leptin signaling pathway.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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Sensitive cilia set up the kidney
Article Abstract:
Mouse knockout experiments have helped in finding out cilia's role in guiding the organ into right shape and also in regulating food intake. The studies have highlighted on the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD) that results in renal failure.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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Upregulation of RGS7 may contribute to tumor necrosis factor-induced changes in central nervous function
Article Abstract:
Tumor necrosis factor prevents the degradation of the RGS7 protein, one of the components of the G protein complex. This could explain how sepsis affects the nervous system, causing fever, lethargy, and anorexia.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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