Operative laparoscopy: a challenge for general gynecology?
Article Abstract:
The surgeon's skill and proper patient selection should be the determining factors in deciding whether a laparoscopic approach is surgically appropriate. A laparoscope is a thin optic instrument that is inserted through a small incision in the abdominal wall to allow doctors to see the fallopian tubes and ovaries. Laparoscopic techniques are useful for a variety of gynecologic surgeries, but there are times when more traditional methods may be more appropriate. One benefit of laparoscopic surgery seems to be that it reduces the amount of time patients spend in the hospital after surgery. However, this must be balanced against the high cost of the disposable laparoscopic equipment and the need, in some cases, for the surgeon to make additional incisions. Surgeons should be encouraged to try new techniques when appropriate so that they can develop their expertise and make informed choices about when surgery involving laparoscopy might be appropriate. Evaluation of the patient's condition will also influence the surgeon's choice of technique.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1993
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Selective photosensitizer distribution in vulvar condyloma acuminatum after topical application of 5-aminolevulinic acid
Article Abstract:
Venereal warts caused by human papillomavirus (HPV) infection may be destroyed by photosensitizing therapy. Researchers treated 24 patients with vulvar warts with photodynamic therapy including either a 2.5% 5-aminolevulinic acid ointment or a 20% 5-aminolevulinic acid cream. After application of the drug, fluorescence was initiated by use of an ultraviolet lamp placed 50 cm in front of the vulva. Drug levels were found to be higher with the 2.5% ointment than with the 20% cream 90 minutes after application. None of the women using the 2.5% ointment reported discomfort, while nine using the 20% cream did. The drug cleared the basal skin layer by 24 hours after application, so photodynamic therapy should be performed before this to eradicate HPV from basal skin. The drug is not well absorbed in normal, surrounding skin, and usually does not damage it.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
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Effect of administration route and estrogen manipulation on endometrial uptake of Photofrin porfimer sodium
Article Abstract:
Intrauterine administration of a photosensitizing drug such as Photofrin may be more effective than intravenous or intraperitoneal administration for the treatment of endometrial, or uterine, cancer. The adverse side effects of photosensitizing drugs can be reduced by simultaneous treatment with estrogen. Of 80 female rats injected with Photofrin, 25 received an intrauterine injection, 26 received an intravenous injection and 12 received an intraperitoneal injection. Seventeen rats received no treatment. Uptake of Photofrin by endometrial tissue was significantly higher in rats who received intrauterine Photofrin than in those who received intravenous or intraperitoneal Photofrin. Simultaneous treatment with estrogen increased the uptake of Photofrin uptake by endometrial tissue and reduced its toxicity.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1993
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