Orchestrating sleep-wake functions in the brain

Article Abstract:

Research shows that feedback loops of the neurotransmitter hypocretin and glutamate neurons mediate the neuronal output, which regulates arousal. Data indicate that hypocretin excites hypocretin neurons via local glutamate neurons and furthermore, the arousal and sleep-wake functions are regulated by harmonized activity of many neuronal areas.

Germany, Physiological aspects, Sleep, Neurotransmitters, Wakefulness

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Reticulon family members modulate BACE1 activity and amyloid-B peptide generation

Article Abstract:

Reticulon proteins block access of BCAE1 to amyloid precursor protein and reduce the cleavage of this protein is presented. Changes in the expression of reticulon protein in the human brain affect cellular amyloid-beta and the formation of amyloid plaques.

Amyloid beta-protein

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Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease

Article Abstract:

A novel protein, kielin/chordin-like protein,(KCP) with 18 cysteine-rich domains is described. The result indicates an important role for KCP in attenuating the pathology of renal fibrotic disease.

Kidney diseases, Cysteine

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