PET detection of viable tissue in myocardial segments with persistent defects at Tl-201 SPECT
Article Abstract:
The hearts of 26 patients with apparent areas of damage to the muscular wall (myocardium) following various degrees of ischemic heart disease (decreased arterial blood supply to the myocardium) were evaluated by single photon emission computed tomography (SPECT). During a SPECT test the patient is given an injection of a radioactive compound, in this case thallium (Tl-201), and a detector (a nuclear camera) is moved to survey the body. In this study patients who demonstrated segmental defects during the SPECT test were subjected to a more advanced PET examination (positron emission tomography) in which radioactive glucose is injected into the body and the heart's uptake is visualized. Of 142 segments which were defective on Tl scan, 101 had fixed defects and the remain 41 had defects which were reversible to some degree on PET imaging. Surprisingly 47 percent of the segments with fixed defects and nearly 65 percent of areas with partially reversible defects showed continued utilization of myocardial glucose by PET. These data suggest that thallium SPECT overestimates the degree of myocardial damage following a heart attack.
Publication Name: Radiology
Subject: Health
ISSN: 0033-8419
Year: 1989
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Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf animals
Article Abstract:
Atoh1 gene therapy is used to induce regeneration of hair cells and substantially improve hearing thresholds in the mature deaf inner ear after delivery to nonsensory cells through adenovectors. The results suggest a new therapeutic approach based on expressing crucial development of genes for cellular and functional restoration in the damaged auditory epithelium and other sensory systems in deaf animals.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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Quantification of target gene expression by imaging reporter gene expression in living animals
Article Abstract:
A new technology for quantifying therapeutic gene expression using positron emission tomography (PFT) reporter gene technique and constructing bi-cistronic vectors is reported. The system consists of a common promoter directing a single mRNA molecule containing coding regions of target gene and a PFT reporter gene co-expressed by encephalomyocarditis virus genetic apparatus.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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