The role of PPAR-gamma in macrophage differentiation and cholesterol uptake
Article Abstract:
Research presented concerns the role of peroxisome proliferator-activated receptor-gamma, a ligand-dependant transcription factor, in the regulation of macrophage functions. Topics addressed include myeloid development, cell receptor expression, and macrophage foam-cell formation.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway
Article Abstract:
Research presented concerns the expression of peroxisome proliferator-activated receptors (PPAR)- alpha and gamma in human macrophage cells. Researchers study the role of PPAR-activators in foam cell formation and cholesterol metabolism, as well as the regulation of the ABCA1 pathway in patients with Tangier disease.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways
Article Abstract:
Atherosclerotic lesion development in myeloid differentiation protein-88 (MYD88)-null mice is examined. Findings link elevated serum lipid levels to proinflammatory signaling cascade that is also engaged by microbial pathogens.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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